In the world the first calcium channel retarder has been published since 1960, some many kind of calcium ion channel retarder applies one after another to clinically treats the hypertension, the angina pectoris, the arteriosclerosis and so on and obtains successfully. Along with the calcium ion channel retarder widespread clinical practice, its side effect also along with it appearance, the new calcium oppresses the anti- medicinal preparation also along with it production. This article summarized the recent years calcium to oppress the anti- medicinal preparation research and the development new variety, introduced its Pharmacology characteristic, has appraised them in the cardiovascular medicine status. To it not good responded conducts the detailed analysis research, gives the reasonable appraisal, the instruction clinical reasonable use, reduces not good responds the occurrence, simultaneously promotes the new medicine and the dosage-form product development, displays clinical value which this kind of medicine should have. The calcium oppresses the anti- medicinal preparation application prospect extremely broadly, the market potential is extremely huge.